In chamber experiments, we investigated the ventilation effectiveness and thermal comfort of a task ventilation system with an air supply nozzle located underneath the front edge of a desk and directing air towards a heated mannequin or a human volunteer seated at the desk. The task ventilation system provided outside air, while another ventilation system provided additional space cooling but no outside air. Test variables included the vertical angle of air supply (−15° to 45° from horizontal), and the supply flow rate of (3.5–6.5 l/s). Using the tracer gas step-up and step-down procedures, the measured air change effectiveness (i.e., exhaust air age divided by age of air in the breathing zone) in experiments with the mannequin ranged from 1.4 to 2.7 (median, 1.8), whereas with human subjects the air change effectiveness ranged from 1.3 to 2.3 (median, 1.6). The majority of the air change effectiveness values with the human subjects were less than values with the mannequin using comparable tests. Similarly, the tests run with supply air temperature equal to the room air temperature had lower air change effectiveness values than comparable tests with the supply air temperature lower (∼5°C) than the room air temperature. The air change effectiveness values are higher than typically reported for commercially-available task ventilation or displacement ventilation systems. Based on surveys completed by the subjects, operation of the task ventilation system did not cause thermal discomfort.